http://hdl.handle.net/123456789/2147 البحث عن قناة بحث http://repository.ksu.edu.sa/jspui/simple-search http://hdl.handle.net/123456789/6608 العنوان: Documentation of pharmacist's intervantions in Riyadh hospitals<br/><br/>المؤلفون: Al-Ahdal, Abdulrahman M.; Abou-Auda, Hisham S.; Daghash, Hadeel M.<br/><br/>ملخص: The purpose of this study was to evaluate the rate of and barriers to documentation of hospital pharmacists working in Riyadh, Saudi Arabia. A three-section, seven-page questionnaire was designed and distributed to 550 pharmacists in 16 hospitals. Responses to each question were coded individually, and a computer program was developed using the Statistical Package for Social Sciences (SPSS) for Windows (version 10). Of the 309 surveyed in this study, 301 (97.7%) pharmacists believe that they should document their interventions but, only 114 (36.9%) of them actually do so. Pharmacists with higher education (e.g., M.S., Pharm.D., Ph.D.) have a documentation rate significantly higher (p<0.05) than those with bachelor degrees (76.9% vs. 33.2%). Most of the pharmacists (75.2%) have graduated from King Saud University. Pharmacists graduated from North American universities document interventions at a rate higher than those graduated from Arab and non-Arab universities (69%, 33% and 9%, respectively). The documentation rate widely varied among the 16 hospitals in the range from 0% to 79%. Seventy seven (25%) of the pharmacists were not aware if they have policy and procedure (P&P) for documentation and 47 (15%) stated that they do not have P&P for pharmacists' documentation. Five major documentation-related barriers were identified. These include no time to document (59.3%), no existing system (50.3%), no access to patient’s file (26.7%), not permitted per policy (22.1%), and no need to document (3.6%). The results of this study are important for the future of the pharmacy profession in Saudi Arabia. Belief, educational, and pharmacy management systems of the Pharmacist are possible reasons for the low documentation rate in this study. Recommendations to improve the documentation rate of pharmacists’ interventions are discussed.<br/><br/>وصف: Department of Clinical PharmacyCollege of Pharmacy, King Saud UniversityP.O. Box 2457, Riyadh 11451, Saudi Arabia http://hdl.handle.net/123456789/6280 العنوان: A Study of the effects of different disinfectants used in riyadh hospitals and their efficacy against methicillin resistant staphylococcus aureus (MRSA)<br/><br/>المؤلفون: Baddour, Manal M<br/><br/>ملخص: Methicillin resistant Staphylococcus aureus (MRSA) and the means of controlling it,continue to be of major interest to the healthcare community. The bactericidal activityof some disinfectants which are in common use in seven major tertiary care hospitals inRiyadh was tested against two control strains of S. aureus, namely MRSA ATCC 33591and Methicillin sensitive Staphylococcus aureus (MSSA) ATCC 29213. Thedisinfectants tested in this study were a group used for hand antisepsis (Purell, EZclean,Cida stat and Manorapid Synergy) and another group used for environmentaldisinfection (Combi spray, Tristel fusion, Alphadine, Isopropanol, Presept and Diesin).Presept, diesin and tristel fusion had a remarkable effect on the tested strains, bothmethicillin sensitive and methicillin resistant. There was hardly any noticeabledifference between the effects on either (P> 0.05). On the other hand, Purell and EZcleanand Manorapid Synergy hand rubs had a relatively weak action after 15 and 30minutes while their effect was better after 1 and 2 hours. There were no observabledifferences between their effects on MRSA or MSSA, P>0.05. Cida stat had aremarkably pronounced effect against both MRSA and MSSA. Contrary to someprevious reports, this study has also proven that chlorhexidine and quaternaryammonium compounds show comparable efficacy against both MRSA and MSSA. http://hdl.handle.net/123456789/5844 العنوان: Influence of fluvoxamine administration on glibenclamide pharmacokinetics after multiple oral dosing in rats<br/><br/>المؤلفون: Radwan, Mahasen A; Zaghloul, Iman Y; Al-Hadiyah, Badraddin M; Al-Khamis, Khalil I<br/><br/>ملخص: Administration of fiuvoxamine did not significantly alter glibenclamide pharmacokinetic parameters. Further studies in diabetic rats or human should be performed, for a long period of time, to demonstrate if such interactionbetween fiuvoxamine and glibenclamide is of pharmacokinetic and/or pharmacodynamic significance. http://hdl.handle.net/123456789/5073 العنوان: Evaluation of the effects of rofecoxib and nitric oxide-releasing aspirin on stress-Induced gastric ulcers in rats<br/><br/>المؤلفون: Khalifa, Mohamed Montaser A.; Abdel-Al, Magdy K.; El-Moselhy, Mohamed A.; Fadel, Al-Shaimaa F.<br/><br/>ملخص: The study was conducted to investigate possible mechanisms of the protective actions of rofecoxib (a selective COX-2 inhibitor) and nitric oxide-releasing aspirin (NO-aspirin) againstexperimentally induced gastric lesions in rats. The rats were randomly assigned to vehicle(carboxymethylcellulose), rofecoxib (5 mg/Kg) and NO-aspirin (55mg/Kg)-pretreated groups, inaddition to the non-stressed control group. Gastric lesions were induced by exposing the rats to 3hrs cold restraint stress (CRS) and ulcer indices were determined. Gastric juice parameters (pH,free and total acid output, mucin and pepsin concentrations) were determined. The stomachs wereused for determination of gastric mucosal level of lipid peroxides as well as total nitrites. Resultsshowed that both rofecoxib and NO-aspirin displayed protective effects against lesions formation.Pretreatment with both drugs significantly lowered gastric acid secretion, mucin and pepsinconcentrations as well as mucosal levels of lipid peroxides and total nitrites compared to CRSrats. This protection was possibly mediated through lowering of gastric juice acid secretion andproteolytic activity and increasing mucin concentration as well as free radical scavenging and reduction of the detrimental increase of nitric oxide during CRS.