http://hdl.handle.net/123456789/2223 البحث عن قناة بحث http://repository.ksu.edu.sa/jspui/simple-search http://hdl.handle.net/123456789/7986 العنوان: Knowledge and practices of childhood immunization among primary health care providers in Riyadh city: part II-precautions and contraindications to vaccination<br/><br/>المؤلفون: Al-Ayed, Ibrahim H.; Sheik, Shaffi<br/><br/>ملخص: Objectives: To assess 1) how aware those who administer vaccines in the primary healthcare centres (PHCs) are of the appropriate precautions and contraindicaitons of vaccinesand 2) the extent to which their practice complies with standards, and 3) the correlationbetween the levels of knowledge and practice on one hand with the duration of practice andattendance at a training course on vaccination on the other hand, for physicians and nursesseparately.Methods: A self-adminstered questionnaire including 16 statements related to knowledgeand practice of precautions and contraindications of vaccines was distributed amongworkers in 50 MOH PHCs in Riyadh.Results: 506 questionnaires were returned, only 331 were completed for this part of thestudy giving a response rate of almost 65%. However, the statement-specific response ratevaried. Except for a few, most statements were correctly responded to by a majority of therespondents reflecting adequate knowlegde and appropriate practice. Experience in dealingwith vaccination, and formal training in vaccination were not statistically significantlyassociated with the responses of both physicians and nurses.Conclusion: Inspite of the limitations of this study it could be fairly concluded that theoverall knowledge and practices regarding precautions and contraindications of childhoodimmunizations among the primary care providers surveyed was good. Significant gaps still exist.This underlines the need for continuous training and supervision of health care providers whodeal with the immunization of children. Sun, 01 Jan 2006 00:00:00 GMT http://hdl.handle.net/123456789/7902 العنوان: Nutritional rickets and osteomalacia in school children and adolescents (6-18 years) in a major teaching hospital in Riyadh, Kingdom of Saudi Arabia<br/><br/>المؤلفون: Al-Jurayyan, Nasir .A.; El-Desouki, Mahmoud E.; Al-Herbish., Abdullah S.; Al-Mazyad, Abdullah S.; Al-Qhtani, Maha M.<br/><br/>ملخص: Objectives: To review experiences of nutritional rickets and osteomalacia in school children and adolescents at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. Methods: Records of children and adolescents aged 6-18 years, seen at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia, during the period January 1994 through to December 1999, who were diagnosed to have rickets or osteomalacia were reviewed. The diagnosis was based on clinical, biochemical and radiological data. Data extracted and analyzed included age, sex, presenting symptoms and signs, dietary history and sun exposure, blood count, bone profiles, renal and liver profile, and 25-hydroxy vitamin D3 and 1, 25 dihydroxy vitamin D3. Hand and wrist x-rays were carried out for all patients while bone density of lumbar spine and 3 femoral sites and bone scan were performed on the majority of patients. Results: Forty-two children and adolescents (25 females and 17 males) were diagnosed. Their age ranged between 6-18 years with a mean of 13.5. Non specific symptoms, such as bone pain and fatigue were the most presenting symptoms, while skeletal deformities and fractures were the presenting symptoms in only 5 and 3 patients. Lack of direct sun exposure and poor calcium intake was evident. Bone profiles at the time of diagnosis revealed mean serum calcium of 2.1 mmol/L, range 1.5–2.3 (Normal=2.2-2.7), phosphorus 1.1 mmol/L, range 0.7–1.9 (Normal=1.4–2.1) and alkaline phosphatase activities of 1,480 U/L, range 834 – 2,590 (N=<600). Serum concentrations of 25-hydroxy Vitamin D were low (<10 mg/L) while that of 1, 25 Dihydroxy Vitamin D varied between low to normal (<10-45 ng/L). Bone density of the lumbar spine and 3 femoral sites were performed in 26 patients and showed markedly reduced values, while bone scan demonstrated a high uptake of tracer throughout the skeleton "super scan". Multiple stress fractures were evident in 8 children. Conclusions: Although a community-based study to assess the magnitude of the problem is needed, it seems that rickets and osteomalacia of nutritional origin are not that uncommon and deserves special attention from all pediatricians and practicing physicians. They also suggested that further studies are needed to help understand the pathophysiology, and identify the contributing factors for the development of the disorder.<br/><br/>وصف: (1) Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, ARABIE SAOUDITE(2) Department of Nuclear Medicine, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, ARABIE SAOUDITE Tue, 01 Jan 2002 00:00:00 GMT http://hdl.handle.net/123456789/7894 العنوان: Effect of Short-Term Use of Different Non-Steroidal Anti-Inflammatory Drugs on Renal Function During Fasting in Ramadan<br/><br/>المؤلفون: Al-Arfaj, Hussein F.; Alballa, Suliman .R; Alhaider, Abdulqader A.; Huraib, Sameer O.; Al-Arfaj, Abdurahman; Bamgboye, Elijah<br/><br/>ملخص: This study was conducted to determine the combined effect of Ramadan fasting and short-term use of different non-steroidal anti-inflammatory drugs (NSAIDs) on renal function in healthy volunteers. The study subjects were assigned to six different groups, five of whom took different NSAIDs (namely nabumetoce, indotaethacin, diclofenac, sulindac, tenoxicam) and the sixth was a control group. Data were collected on serum sodium, chloride, potassium, urea; creatinine, bicarbonate and uric acid as well as urinary osmolarity, sodium, potassium, chloride and urea. These measurements were taken before fasting, 10 days into fasting while using NSAIDs, and five days after stopping the use of NSAIDs. The results showed slight changes in serum and urine measurements during fasting while using NSAIDs. These changes, although were significant in some cases, were within the normal range and were noted in all the study groups including the control group We conclude that short-term use of NSAIDs in healthy subjects during fasting is not associated with any major adverse effects on the renal function. Sun, 01 Jan 1995 00:00:00 GMT http://hdl.handle.net/123456789/7893 العنوان: Novel 5-flucytosine-resistant clade of candida dubliniensis from Saudi Arabia and Egypt identified by Cd25 fingerprinting<br/><br/>المؤلفون: Al-Mosaid,Asmaa; Sullivan, Derek J.; Polacheck, Itzhack; Shaheen, Faisal A.; Soliman, Osama; Al-Hedaithy, Saleh; Al-Thawad, Sahar; Kabadaya, Motaz; Coleman, David C.<br/><br/>ملخص: DNA fingerprinting of Candida dubliniensis isolates using the species-specific probe Cd25 previously showedthat this species consists of two distinct groups, termed Cd25 group I and Cd25 group II. The present studyinvestigated the population structure of 30 C. dubliniensis oral isolates from Saudi Arabia and Egypt usingCd25 fingerprinting and rRNA gene internal transcribed spacer region-based genotyping. Cd25 fingerprintinganalysis of these isolates revealed two distinct populations, the first of which consisted of 10 closely relatedgenotype 1 isolates (average similarity coefficient [SAB] value, 0.86). The second population of 20 isolates wasmuch more heterogeneous (average SAB value, 0.35) and consisted of two distinct subpopulations, one of whichconsisted of genotype 3 isolates (n = 13) and the other of genotype 4 isolates (n = 7). A mixed dendrogramgenerated from the fingerprint data from the 30 Saudi Arabian and Egyptian isolates, 5 Israeli isolates, and51 previously characterized international isolates (32 of Cd25 group I and 19 of Cd25 group II) revealed thepresence of three distinct main clades. The first corresponded to the previously described Cd25 group I andcontained all the Saudi Arabian, Egyptian, and Israeli genotype 1 isolates mixed with international isolates.The second clade corresponded to the previously described Cd25 group II and contained three Israeli isolates,one genotype 2 isolate, one genotype 3 isolate, and a genotype 4 variant isolate, which were mixed withinternational isolates. The third clade has not been described before and consisted solely of the 20 SaudiArabian and Egyptian genotype 3 and 4 isolates identified in this study and a previously described genotype4 Israeli isolate. All 20 Cd25 group III isolates exhibited high-level resistance to 5-flucytosine (MIC >= 128ug/ml), whereas all Cd25 group I and Cd25 group II isolates tested (10 Saudi Arabian and Egyptian, 16 Israeli,and 24 international) were susceptible to 5-flucytosine (MIC <= 0.125 ug/ml). The results of this study show forthe first time the presence of a novel 5-flucytosine-resistant clade of C. dubliniensis (Cd25 group III) that ispredominant among isolates from Saudi Arabia and Egypt and absent from a previously characterizedinternational collection of 98 isolates from 15 countries.<br/><br/>وصف: Microbiology Research Division, Dublin Dental Microbiology Research Division, Dublin Dental School and Hospital, Trinity College, University of Dublin, Dublin 2,Republic of Ireland1; Department of Clinical Microbiology and Infectious Diseases, The HebrewUniversity-Hadassah Medical Center, Jerusalem, Israel2; Jeddah Kidney Center, King FahadHospital, Jeddah, Saudi Arabia3; National Cancer Institute, Cairo, Egypt4; Medical MycologyUnit, Department of Pathology, College of Medicine, King Khalid University Hospital,Riyadh, Saudi Arabia5; and Microbiology Laboratory, Department ofPathology & Laboratory Medicine, King Faisal SpecialistHospital and Research Center, Riyadh, Saudi Arabia. Sat, 01 Jan 2005 00:00:00 GMT