Effects of streptozotocin on the molybdenum hydroxylases activities of the rabbits and the guinea pigs

Abstract

Effects of streptozotocin on the molybdenum hydroxylases, aldehyde oxidase and xanthine oxidase activities on some organs of the rabbits and guinea pigs were investigated. Rabbits and giunea pigs were treated with streptozotocin (65 mg/kg body weight) using a single intrapertitoneal injection. The food intake of treated rabbits was significantly lowered (P<0.005) on the second day of treatment. The levels of plasma glucose of treated rabbits were significantly decreased (P<0.05). No effect of streptozotcin on rabbits aldehyde oxidase activity was observed. The guinea pigs treated with streptozotocin showed significant decreases in aldehyde oxidase activities of the tissues of duodenum (P<0.03), spleen (P<0.005) and brain (P<0.005) using 3-methylisoquinoline as a substrate. Although the activity of brain aldehyde oxidase from treated guinea pigs was increased significantly (P<0.05) using phthalazine as a substrate, these differ-ences in brain aldehyde oxidase activities suggested that the isoenzymes of aldehyde oxidase are involved in these interactions. Furthermore, the activity of duodenal xanthine oxidase from treated guinea pigs was lower significantly (P<0005) than the control animals. The present study revealed that the rabbits and guinea pigs molybdenum hydroxylases differ markedly in respect of their effects on streptozotocin. Keywords: Molybdenum hydroxylases, Aldehyde oxidase, Xanthine oxidase, Streptozotoicin.