Novel method for the determination of isoprenaline in a pharmaceutical preparation by differential-pulse voltammetry

Abstract

A differential-pulse voltammetric procedure is described for the determination of Iow concentrations of isoprenaline in pure form in a pharmaceutical preparation. At pH 0.5 and with 0.1 M potassium nitrate as the base electrolyte, the electrode response was linearly proportional to the concentration of isoprenaline in the range 10¯5-10¯2 M. The detection limit was 1x 10¯6 M and the relative standard deviation (n=10) was 1.2% at 4xl0¯4 M isoprenaline. The degree of interference from some excipients, added to the pharmaceutical product, on the differential pulse voltammetric signal for isoprenaline was evaluated. No matrix separation is required.