Conductometric titrations of hydralazine hydrochloride using chloranilic acid and ammonium reineckate

Abstract

A simple, rapid and sensitive conductometric titration method was desigend to determine hydralazine hydrochloride concentrations in the range of 0.20-23.0 mg using a chloranilic acid and ammonium reineckate as titrants. The effect of the solvent ratio, reagent concentration, time equilibrium and temperature on the shape of the titration curve was studied. Statistical treatment of the experimental results indicates that this method is precise and accurate. The accuracy of the method is indicated by the excellent recovery, i.e. ( 99.9-100.1 %) and the precision is supported by the low standard deviation value (i.e. 0.1 ). The sensitivity of the proposed method is discussed and the results are compared withthe pharmacopoeial method. Keywords: Hydralazine, chloranilic acid, reineckate, conductometric, titration.