Angiolymphoid hyperplasia with eosinophilia (ALHE)

Abstract

A 16-year old girl reported with a dome shaped, smooth-surfaced subcutaneous nodule in the left submandibular area of 8 months duration. Absence of relevant positive findings lead to the provisional diagnosis of benign submandibular gland neoplasm or reactive lymphadenitis of neck. As excision biopsy was performed of the lesion and the wound primarily closed. The surgical section revealed a mixed inflammatory dermal infiltrate with lymphocytes and numerous eosinophils and proliferation of blood vessels with plump endothelial cells protruding into the lumen. The overlying epidermis was hyperplastic. A histologic diagnosis of ALHE was made and the patient was managed surgically. She underwent an uneventful recovery. A follow up of 6 months post-operatively failed to notice any recurrence.