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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14848

Title: Computer Simulation of Trabecular Remodeling Using a
Authors: S. TAYYAR.
S. WEINHOLD
R. A. BUTLER
J. C. WOODARD
L. D. ZARDIACKAS
Keywords: Computer simulation
Trabecular remodeling
Bone loss
Perforation
Basic multicellular
unit (BMU) activation rate
Issue Date: 1999
Publisher: Elsevier Science Inc.
Abstract: A simplified three-dimensional simulation of trabecular bone remodeling has been developed. The model utilizes 441 planar structural units to represent approximately 50 mm3 of initial bone volume with 199 basic multicellular units (BMUs). The simulation takes into account trabecular perforation in the structural model. The cases of male bone remodeling with no menopause and female bone remodeling with menopause are examined from the period of simulated age 25–80 years. Menopause is arbitrarily started at age 45 and extends for 7.5 years. Zero-, first-, and second-order BMU activation responses are employed to examine how the bone would be affected by the method of increase of BMU activation during menopause. At age 80, the female bone remodeling simulation produced a bone volume loss of approximately 49% for all three activation responses. This compared to a 38% bone volume loss for the case of no menopause. For the menopause simulations, an average of about 40% of the total bone loss was due to perforation.
URI: http://hdl.handle.net/123456789/14848
Appears in Collections:College of Applied Medical Sciences

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