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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14865

Title: Kinetics of the effect of crude Cerastes cerastes gasperetti venom
Authors: H.K. Ghneim
F.J. Al•Shammary
Keywords: Cerastes cerastes gasperetti. citrate synthase.
Issue Date: 1993
Publisher: Med. Sci. Res
Abstract: Reported properties of venom proteins include neurotOxic and cytotoxic effects. defects in coagulation and effects from the local release of substances by enzymatic action [11. Severe haemorrhage around the site of the bite has been associated with vipered envenomation (2], attributed to proteolytic activities of venom haemorrhagic factors (3]. However. venom proteins free from proteolytic activities have been reported [4]. Cerastes cerastes gaspererri (the horned viper), is widely distributed throughout Africa and Southwestern Asia, and is the commonest snake in Saudi Arabia. We have recently studied the effect of a crude extract of the species venom on the activity of key enzymes of metabolism using cultured human fibroblasts [5). Dramatic reductions in the specific activities of glucose and glycogen degradative enzymes were observed. The most pronounced inhibitory effect was with citrate synthase activity. which dropped to 23.7 ± 3.9% of control activity when a flask of confluent cells was Incubated with 25 )J.g of crude venom for :> h. Under the same experimental conditions. creatine kinase activity almost doubled (187.8 ± 13.8% of control activity
URI: http://hdl.handle.net/123456789/14865
Appears in Collections:College of Applied Medical Sciences

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