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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14879

Title: Ultra structural variations of rat myocardium due
Authors: Fahad J. AI-Shammary
Saad S. AI-Saleh
Sameh E. EI-Shewemi
Keywords: ultrastructure, Walterinnesia aegyptia,
myocardium
Issue Date: 1998
Publisher: Japanese Society of Electron Microscopy
Abstract: This study was undertaken to investigate the toxic effect of Walterinnesia aegyptia venom on the ultrastructure of rat myocardium. Male albino rats were prepared for intraperitoneal injection of saline (control group) and saline solution of w.aegyptia venom (study group) at a dose of 0.04 mg animal-l. Biopsies from the left ventricle were prepared for electron microscopy after 1 h (D1 group), 2 h (D2 group), 18 h (D3 group) and 24 h (D4 group). Myocardial cells were in a state of partial to complete contraction. The D 1 group showed some mitochondrial vacuoles; D2 group demonstrated more vacuolation and alterations in the form of disorganized cristae. Similar findings were depicted in D3 group. The D4 group demonstrated, in addition, dissolution of mitochondrial cristae. Myofilaments in D3 group experienced coalescence into ill-defined amorphous masses (foci of myolysis). These masses were characterized by the presence of multiple, parallel. Z-like dark bands with disorganization of the filamentous arrangement. In the D4 group, more myolytic foci were observed. This reaction was not limited to one myocyte but extended to the neighbouring ones. Mitochondrial vacuoles were mostly associated with electron dense deposits. Glycogen particles tended to decrease as the experiment proceeded from D 1 to D4. These ultrastructural changes were time dependent. They would suggest a cardiotoxic action of w.aegyptia snake venom.
URI: http://hdl.handle.net/123456789/14879
Appears in Collections:College of Applied Medical Sciences

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