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|Title: ||Accelerated alveolar bone loss in mice lacking interleukin-10: late onset|
|Authors: ||Al-Rasheed, A.|
|Keywords: ||Alveolar bone loss; bone resorption; C-telopeptide; disease models; interleukin-10; mice; knockout|
|Issue Date: ||2004 |
|Publisher: ||Blackwell Publishing Inc.|
|Citation: ||Journal of Periodontal Research; 39(3):194-198|
|Abstract: ||Objective and background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine regulating immune responses. We have previously reported that IL-10(–/–) mice experience accelerated alveolar bone loss. The purpose of the present study was to examine the timing of the manifestation of accelerated alveolar bone loss in IL-10(–/–) mice.
Materials and methods: Twenty-four IL-10(–/–) and 21 IL-10(+/+) age-matched male 129/SvEv mice were used. Sacrifice times occurred at 1, 3 and 9.5 months of age. Alveolar bone loss was determined morphometrically on defleshed jaws. Enzyme-linked immunosorbent assay (ELISA) was used for determination of serum concentration of type I collagen C-telopeptide, a systemic marker of bone resorption.
Results: Alveolar bone loss for the entire IL-10(–/–) group was significantly different than for the IL-10(+/+) group (p = 0.025). There was no significant difference in alveolar bone loss between IL-10(–/–) and IL-10(+/+) mice at 1 and 3 months of age. At 9.5 months of age, IL-10(–/–) mice exhibited 39% greater alveolar bone loss than IL-10(+/+) mice (p = 0.018). For IL-10(–/–) mice, alveolar bone loss significantly increased with age. Serum C-telopeptide levels significantly decreased with age in both groups. IL-10(–/–) mice had consistently higher C-telopeptide levels than IL-10(+/+) mice and the difference between the two groups reached statistical significance (p = 0.011) for the 9.5-month-old mice.
Conclusions: These results suggest that the accelerated alveolar bone loss observed in IL-10(–/–) mice is a late-onset condition and that lack of IL-10 may have an effect on bone homeostasis.|
|Appears in Collections:||College of Dentistry|
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