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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/16085

Title: Accelerated alveolar bone loss in mice lacking interleukin-10: late onset
Authors: Al-Rasheed, A.
Scheerens, H.
Srivastava, A.
Rennick, D.
Tatakis, D.
Keywords: Alveolar bone loss; bone resorption; C-telopeptide; disease models; interleukin-10; mice; knockout
Issue Date: 2004
Publisher: Blackwell Publishing Inc.
Citation: Journal of Periodontal Research; 39(3):194-198
Abstract: Objective and background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine regulating immune responses. We have previously reported that IL-10(–/–) mice experience accelerated alveolar bone loss. The purpose of the present study was to examine the timing of the manifestation of accelerated alveolar bone loss in IL-10(–/–) mice. Materials and methods: Twenty-four IL-10(–/–) and 21 IL-10(+/+) age-matched male 129/SvEv mice were used. Sacrifice times occurred at 1, 3 and 9.5 months of age. Alveolar bone loss was determined morphometrically on defleshed jaws. Enzyme-linked immunosorbent assay (ELISA) was used for determination of serum concentration of type I collagen C-telopeptide, a systemic marker of bone resorption. Results: Alveolar bone loss for the entire IL-10(–/–) group was significantly different than for the IL-10(+/+) group (p = 0.025). There was no significant difference in alveolar bone loss between IL-10(–/–) and IL-10(+/+) mice at 1 and 3 months of age. At 9.5 months of age, IL-10(–/–) mice exhibited 39% greater alveolar bone loss than IL-10(+/+) mice (p = 0.018). For IL-10(–/–) mice, alveolar bone loss significantly increased with age. Serum C-telopeptide levels significantly decreased with age in both groups. IL-10(–/–) mice had consistently higher C-telopeptide levels than IL-10(+/+) mice and the difference between the two groups reached statistical significance (p = 0.011) for the 9.5-month-old mice. Conclusions: These results suggest that the accelerated alveolar bone loss observed in IL-10(–/–) mice is a late-onset condition and that lack of IL-10 may have an effect on bone homeostasis.
URI: http://hdl.handle.net/123456789/16085
ISSN: 0022-3484
Appears in Collections:College of Dentistry

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