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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/16985

Title: Rapid micromethod for simultaneous measurement of oxcarbazepine and its active metabolite in plasma by high
Authors: Matar, K M;
Nicholls, P J
al-Hassan, M I
Issue Date: 1995
Publisher: J Clin Pharm Ther
Abstract: A rapid method for the simultaneous determination of oxcarbazepine (OXC) and its active metabolite (10-hydroxycarbazepine) in human and rat plasma by reversed phase high-performance liquid chromatography is described. The method involves a simple one-step extraction of the drugs from plasma with dichloromethane. The extract was evaporated and the residue was reconstituted with mobile phase and injected onto a Novapak C18 column. The eluting solvent was 20% acetonitrile in water at a flow rate of 1.5 ml/min and the detector was monitored at 215 nm. The detection limit of OXC and 10-hydroxycarbazepine was 50 and 20 ng/ml, respectively. The within-day and between-day coefficients of variation for OXC and its active metabolite were 2.57-6.95% and 4.21-8.3%, respectively. The relative and absolute recoveries varied between 71.4% and 104.0%. The applicability of the analytical procedure to pharmacokinetic studies was illustrated.
URI: http://hdl.handle.net/123456789/16985
Appears in Collections:College of Pharmacy

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