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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17015

Title: Effect of pirenzepine on the N-demethylation of D(-)ephedrine and ethylmorphine by rabbit liver microsomes.
Authors: el-Obeid HA
al-Rashood KA
al-Khamees HA
al-Khamis KI
Issue Date: 1993
Publisher: LANL
Abstract: The possible interaction of pirenzepine with the mixed-function oxidases obtained from phenobarbital-pretreated rabbit microsomes was examined in vitro. Under experimental conditions that did not lead to its own N-demethylation, the drug inhibited the microsomal oxidase systems responsible for the N-demethylation of D(-)ephedrine and ethylmorphine. Kinetic studies showed that pirenzepine inhibited the metabolism of both drugs in a competitive manner. The results indicated that the observed pirenzepine stability to the hepatic N-demethylating system is not a result of low affinity of the drug to the system.
URI: http://hdl.handle.net/123456789/17015
Appears in Collections:College of Pharmacy

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