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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17059

Title: Membrane sensors for the selective determination of donepezil hydrochloride.
Authors: Gamal Abdel Hafiz Mostafa
Mohamed Hefnawy
Abdulrahman Al-Majed
Keywords: Cholinesterase Inhibitors, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Electrodes, Hydrogen-Ion Concentration, Indans, Ions, Membranes, Artificial, Models, Chemical, Molybdenum, Phosphoric Acids, Phosphotungstic Acid, Piperidines, Potentiometry, Reproducibility of Results, Tetraphenylborate, Time Factors, chemistry, methods
Issue Date: 2010
Publisher: J AOAC Int
Abstract: The construction and electrochemical response characteristics of polyvinylchloride (PVC) membrane sensors for donepezil HCl (DP) are described. The sensing membranes incorporated ion-association complexes of DP cation and sodium tetraphenyl borate (sensor 1), phosphomolybdic acid (sensor 2), or phosphotungstic acid (sensor 3) as electroactive materials. The sensors displayed a fast, stable, and near-Nernstian response over a relatively wide DP concentration range (1 x 10(-2) to 1 x 10(-6) M), with cationic slopes of 53.0, 54.0, and 51.0 mV/ concentration decade over a pH range of 4.0 to 8.0. The sensors showed good discrimination of DP from several inorganic and organic compounds. The direct determination of 2.5-4000.0 microg/mL DP showed average recoveries of 99.0, 99.5, and 98.5%, and mean RSDs of 1.6, 1.5, and 1.7% at 100.0 microg/mL for sensors 1, 2, and 3, respectively. The proposed sensors have been applied for direct determination of DP in two pharmaceutical preparations. The results obtained for determination of DP in tablets using the proposed sensors compared favorably with those obtained using an HPLC method. The sensors have been used as indicator electrodes for potentiometric titration of DP
URI: http://hdl.handle.net/123456789/17059
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