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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17087

Title: Voltammetric determination of montelukast sodium in dosage forms and human plasma
Authors: Alsarra a
M. Al-Omar b
E.A. Gadkariem b
Keywords: Voltammetry; Polarography; Capsules; Plasma
Issue Date: 2005
Publisher: ELSEVIER
Abstract: The voltammetric behaviour of montelukast (MKST) was studied using cyclic voltammetry, direct current (DCt), differential pulse polarography (DPP) and alternating current (ACt) polarography. MKST exhibited well-defined cathodic waves over the range pH range 1–5. No anodicwaveswere produced over the same pHrange. At pH 1, the analytical pH; the diffusion current constant (Id)was 2.2 ± 0.01 μA l mmol–1. The current concentration plot was rectilinear over the range 2–20 μg ml–1 with correlation coefficient (n = 10) of 0.9943. The lower limit of detection (S/N = 2) was 0.2 μg ml–1 (3.41 × 10–7 M). The wave has been characterised as being diffusion-controlled, although adsorption phenomenon played a limited role in the electrode reaction. The proposed method was successfully applied to the determination of MKST in commercial tablets, and results were in agreement with those given with a reference HPLC method. The method was further extended to the in vitro determination of the drug in spiked human plasma. The mean % recovery (n = 5) was 101.38 ± 3.85. The number of electrons transferred in the reduction process could be accomplished and a proposal of the electrode reaction was proposed.
URI: http://hdl.handle.net/123456789/17087
Appears in Collections:College of Pharmacy

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