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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17088

Title: 1,3,4-THIADIAZOLES. REGIOSELECTIVE O-DEMETHYLATION ON DEHYDRATIVE CYCLIZATION OF 1-(3,4,5-TRIMETHOXYBENZOYL)-
Authors: Mohamed Al-Omar
Omar A. Al-Deeb
Hamad A. Al-Khamees
Keywords: 1,3,4-Thiadiazoles; N-debenzylation; N-(t-debutylation); selective O-demethylation
Issue Date: 2004
Publisher: Taylor& Francis
Abstract: Cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-substituted thiosemicarbazides 2a–g with sulphuric acid at ambient temperature afforded the selectively demethylated products 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-substituted amino-1,3,4-thiadiazoles 4a–g. Meanwhile, dehydrative cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-(benzyl or t- butyl)thiosemicarbazides 2h,i with sulphuric acid yielded 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-amino-1,3,4-thiadiazole 5. On the other hand, dehydration
URI: http://hdl.handle.net/123456789/17088
Appears in Collections:College of Pharmacy

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