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| Title: | 1,3,4-THIADIAZOLES. REGIOSELECTIVE O-DEMETHYLATION ON DEHYDRATIVE CYCLIZATION OF 1-(3,4,5-TRIMETHOXYBENZOYL)- |
| Authors: | Mohamed Al-Omar
Omar A. Al-Deeb
Hamad A. Al-Khamees |
| Keywords: | 1,3,4-Thiadiazoles; N-debenzylation; N-(t-debutylation); selective O-demethylation |
| Issue Date: | 2004 |
| Publisher: | Taylor& Francis |
| Abstract: | Cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-substituted thiosemicarbazides 2a–g with sulphuric acid at ambient temperature afforded the selectively demethylated products 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-substituted amino-1,3,4-thiadiazoles 4a–g. Meanwhile, dehydrative cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-(benzyl or t- butyl)thiosemicarbazides 2h,i with sulphuric acid yielded 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-amino-1,3,4-thiadiazole 5. On the other hand, dehydration |
| URI: | http://hdl.handle.net/123456789/17088 |
| Appears in Collections: | College of Pharmacy
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