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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17099

Title: The X-Linked Adrenoleukodystrophy (X-ALD) and Oxidative Stress
Authors: Mohamed A. Al-Omar
Keywords: Lorenzo’s oil, adrenoleukodystrophy, adenomyeloneuropathy, oxidative stress, antioxidants
تاريخ النشر: 2006
Publisher: Journal of Herbal Pharmacotherapy
Abstract: Most of the studies indicate that there is as yet no complete cure for X-ALD. However, methods of the treatment seem to slow rather than treat the disease. One method is the use of Lorenzo’s oil in conjunction with a low fat diet, which may help in cerebral X-ALD. X-ALD is in very close resemblance to another neurodegenerative disease, amyotrophic lateral sclerosis (ALS). One of the believed pathomechanisms of ALS is oxidative stress; therefore, this article’s emphasis on the role of reactive oxygen species in X-ALD. The aim of the present study was to review the literature concerning the advances in the treatment of X-adrenoleukodystrophy (X-ALD, OMIM # 300100) in the last two decades and to shed more light on the link between oxidative stress and X-ALD. This review article may point to a deficit in reactive oxygen species (ROS) scavenging and/or ROS overproduction being involved in the aetiopathology of these neurodegenerative diseases. Consequently, one of the useful neuronal rescue strategies could be the treatment with antioxidant agents.
URI: http://hdl.handle.net/123456789/17099
يظهر في المجموعات:College of Pharmacy

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