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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17100

Title: ,3,4-Thiadiazoles, Regioslective O-Demthyltion on Dehydroactive cyclization of 1-(3,4,5-Trimethoxybenoyl)-4-substituted Thiosemicarbazides with Sulphuric acid
Authors: Al-KhameesHamad A.
El-Emam
Ali A.
Keywords: 1,3,4-Thiadiazoles, N-debenzylation, N-(t-debutylation), Selective O-demethylation, Sulphuric Acid
Issue Date: 2004
Publisher: Taylor & Francis
Abstract: Cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-substituted thiosemicarbazides 2a–g with sulphuric acid at ambient temperature afforded the selectively demethylated products 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-substituted amino-1,3,4-thiadiazoles 4a–g. Meanwhile, dehydrative cyclization of 1-(3,4,5-trimethoxybenzoyl)-4-(benzyl or t-butyl)thiosemicarbazides 2h,i with sulphuric acid yielded 2-(4-hydroxy-3,5-dimethoxyphenyl)- 5-amino-1,3,4-thiadiazole 5. On the other hand, dehydration of 2h,i by heating with phosphorus oxychloride yielded 2-(3,4,5-trimethoxyphenyl)-5-amino-1,3,4-thiadiazole 6.
URI: http://hdl.handle.net/123456789/17100
Appears in Collections:College of Pharmacy

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