Opioid Properties of Some Isomeric Derivatives of Phencyclidine

Abstract

The phencyclidine analogues (±)- -, (±)-β-, and (+)- - and (–)- -4-hydroxy-3-methyl-4-phenyl-l-(1-phenylcyclohexyl)piperidine, all with known relative and absolute stereochemistry, have been prepared, and their analgesic potencies related to corresponding prodines. In contrast to the prodines, the (±)- -phencyclidine analogue was a more potent analgesic than its diastereoisomer, while in agreement with observations in the prodine series, the 3R, 4S- -enantiomer displayed substantially greater potency than its mirror image form.