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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17105

Title: Opioid Properties of Some Isomeric Derivatives of Phencyclidine
Authors: A. F. CASY
G. H. DEWAR
O. A. A. AL-DEEB, †
Issue Date: 1992
Publisher: Journal of Pharmacy and Pharmacology
Abstract: The phencyclidine analogues (±)- -, (±)-β-, and (+)- - and (–)- -4-hydroxy-3-methyl-4-phenyl-l-(1-phenylcyclohexyl)piperidine, all with known relative and absolute stereochemistry, have been prepared, and their analgesic potencies related to corresponding prodines. In contrast to the prodines, the (±)- -phencyclidine analogue was a more potent analgesic than its diastereoisomer, while in agreement with observations in the prodine series, the 3R, 4S- -enantiomer displayed substantially greater potency than its mirror image form.
URI: http://hdl.handle.net/123456789/17105
Appears in Collections:College of Pharmacy

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