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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17125

Title: An Unusual “Senseless” 2′,5′-Oligoribonucleotide With Potent Anti-Hiv Activity
Authors: Tarek Aboul-Fadl
Vijai K Agrawal
Robert W Buckheit
Arthur D Broom
Issue Date: 2007
Publisher: Arthur D Broom
Abstract: A new 32-mer 2′,5′-oligoribonucleotide of 1-methyl-6-thioinosinic acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2′,5′-oligonucleotides and the 3′,5′-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase
URI: http://hdl.handle.net/123456789/17125
Appears in Collections:College of Pharmacy

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