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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17126

Title: An unusual "senseless" 2',5'-oligoribonucleotide with potent anti-HIV activity.
Authors: Tarek Aboul-Fadl
Vijai K Agrawal
Robert W Buckheit
Keywords: Anti-HIV Agents, Cell Line, HIV Reverse Transcriptase, HIV-1, Humans, Molecular Structure, Oligoribonucleotides, Protein Structure, Secondary, Reverse Transcriptase Inhibitors, Structure-Activity Relationship, Thionucleotides, chemistry, pharmacology, metabolism
Issue Date: 2004
Publisher: LNCN
Abstract: A new 32-mer 2',5'-oligoribonucleotide of 1-methyl-6-thioinosinic acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2',5'-oligonucleotides and the 3',5'-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase.
URI: http://hdl.handle.net/123456789/17126
Appears in Collections:College of Pharmacy

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