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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17151

Title: Spectrophotometric determination of methoxamine using cerium(IV) in presence of sodium lauryl sulphate and rhodamine-B
Authors: A A Alwarthan
A M al-Obaid
Issue Date: 1997
Publisher: Biomed Anal
Abstract: A sensitive spectrophotometric assay has been developed for the determination of methoxamine in pure dosage form and in its pharmaceutical preparations. The method is based on the acidic oxidation of methoxamine with cerium(IV) in the micellar medium of sodium lauryl sulphate at 96 degrees C. The reaction yields a water-soluble purple product which can be quantified spectrophotometrically at 505 nm. The calibration curve was linear between 1.0 and 20 micrograms ml-1 with a limit of detection 0.5 microgram ml-1. The molar absorptivity at 505 nm is 8.3 X 10(3) iota mol-1 cm-1. The method is simple and rapid since the product is measured directly in solution without extraction.
URI: http://hdl.handle.net/123456789/17151
Appears in Collections:College of Pharmacy

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