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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17172

Title: The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines.
Authors: H A al-Obeid
K A al-Rashood
A A Madani
Issue Date: 1989
Publisher: Pharm. Res
Abstract: The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.
URI: http://hdl.handle.net/123456789/17172
Appears in Collections:College of Pharmacy

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