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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17174

Title: Spectrophotometric determination of tolmetin sodium in capsule dosage form.
Authors: K A Al-Rashood
M E Mohamed
M Al-Awadi
S M Bayomi
Issue Date: 1988
Publisher: Pak J Pharm Sci
Abstract: Two different U.V. spectrophotometric modes, zero-order and first derivative, have been applied for the quantitation of tolmetin sodium (Tolectin 200 mg) in bulk form and in its pharmaceutical formulation. Direct U.V.-measurement of aqueous solution of the drug at 325 nm exhibits significant linearity at the concentration range 0.1-1.5 mg% with a coefficient of variation (C.V.) 0.34%. The first derivative (d'A) spectrophotometric measurements at 342 nm yield results with a C.V. 0.29%. Drug assay of the capsule gives percent contents of 100.42 +/- 0.34 and 100.28 +/- 029 by adopting zero-order and d'A spectrophotometry respectively. The reproducibility and accuracy the two proposed methods have been assessed by employing standard additions technique. Accordingly the percent recoveries obtained were 99.60 +/- 0.22 and 100.16 +/- 026 for the zero order and the d'A-spectrophotometry respectively.
URI: http://hdl.handle.net/123456789/17174
Appears in Collections:College of Pharmacy

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