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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17191

Title: D1-Differential Potentiometric and 1H-NMR Spectrometric Determinations of Ketoconazole and its Formulations
Authors: Mohammad A. Abounassifa
Bahaa-El-Din M. El-shazlya
Issue Date: 1989
Publisher: Analytical Letters
Abstract: Two rapid and direct quantitative assays have been investigated for ketoconazole alone and in tablet form. the first one is a non-aqueous potentiometric titration in which the equivalence point has been located graphically using its distinct and sharp D1differential (peak-shape) potentiograph. the second is based on 1H-NMR spectrometry and involves the integration of the methyl protons-signal of ketoconazole (at 2.07 δ) relative to that of benzocaine (at 1.30 δ) which is used as internal standard. the obtained results were in good agreement with regard to accuracy, precision as well as sensitivity and reproducibility. However, by comparison with the official USP procedure, the two methods were significantly more accurate and more sensitive. the validity of the two methods were confirmed using the authentic addition technique.
URI: http://hdl.handle.net/123456789/17191
Appears in Collections:College of Pharmacy

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