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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17201

Title: Spectrophotometric determination of benazepril in tablets
Authors: I. A. Al-Zaagi
M. A. Abounassif
Keywords: Benazepril; Potassium permanganate; Pharmaceutical preparations; Spectroscopy; Pharmaceutical analysis
Issue Date: 2000
Publisher: Il Farmaco
Abstract: A simple and sensitive spectrophotometric method has been developed for the determination of benazepril HCl in pharmaceutical formulations. The method is based on the reaction of the drug with potassium permanganate in the presence of sodium hydroxide to produce a bluish–green colored species measurable at 609.4 nm. The absorbance–concentration plot is linear over the range 1–8 μg ml−1 with minimum detectability of 0.1 μg ml−1 (2.17×10−7 M). The molar absorptivity was 4.07×104 l mol−1 cm−1 with correlation coefficient (n=6) of 0.9991. The different experimental parameters affecting the development and stability of the color were studied carefully and optimized. The proposed method was applied successfully to the determination of benazepril in its dosage forms, the percentage recoveries ±SD (n=9) were 99.79±1.40 and 100.50±1.48 for tablets containing 10 and 20 mg, respectively. The results obtained were in good agreement with those obtained using a reference spectrophotometric method. The proposed method could be applied to the determination of benazepril in presence of the co-formulated drug, hydrochlorothiazide. A proposal of the reaction pathway was presented.
URI: http://hdl.handle.net/123456789/17201
Appears in Collections:College of Pharmacy

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