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http://hdl.handle.net/123456789/17308
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| Title: | In-Vivo Evaluation of a Bioadhesive Containing Indomethacin Tablets. |
| Authors: | E A Hosny
M A Al-MeshalD |
| Issue Date: | 1994 |
| Abstract: | The relative bioavailability of a bioadhesive containing, directly compressed, tablet formulation against the commercial indomethacin capsules “Indocid, MSD” has been investigated in dogs. The tablets showed a prolongation of the time to reach maximum concentration to 3 hours compared to 2 hours in capsules. They also showed 39% and 184% increase in maximum and minimum plasma concentration, respectively. The relative bioavailability of the tablets is 152% compared to capsules where the tablets showed a mean area under the plasma concentration-time curve of 26 ug.hr/ml compared to 17 ug.hr/ml for capsules.
DOI: 10.3109/03639049409042674 |
| URI: | http://hdl.handle.net/123456789/17308 |
| Appears in Collections: | College of Pharmacy
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