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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17334

Title: QUICK, SIMPLE, AND SENSITIVE HPLC METHOD FOR DETERMINATION OF ISRADIPINE IN PLASMA AND ITS APPLICATION IN PHARMACOKINETIC STUDIES
Authors: Saleh A Al-SuwayehAnal Lett
Issue Date: 2002
Publisher: PMID
Abstract: A quick, simple and sensitive HPLC method for the analysis of isradipine (ISRA) in plasma is described using UV detection in the presence of diazepam as internal standard. The method employs a reverse phase C8 column and a mobile phase containing water : acetonitrile (50 : 50%, v/v) adjusted to pH 4.0 by glacial acetic acid. Separation of ISRA from plasma is achieved by precipitating plasma proteins with acetonitrile. The lower limit of quantification was 1.0 ng/mL with corresponding retention time of 5.80 min. The suitability of the method for pharmacokinetic studies was verified in rabbits dosed with 0.25 mg IV solution of ISRA and consequently, the relevant pharmacokinetic parameters were determined. DOI: 10.1081/AL-120005973 absorption for both formulations. It was concluded that the formulated tableted microspheres provide an acceptable delivery for DTZ over an extended period of time.
URI: http://hdl.handle.net/123456789/17334
Appears in Collections:College of Pharmacy

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