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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/17731

Title: Protective Effect of Origanum majorana L. 'Marjoram' on Various Models of Gastric Mucosal Injury in Rats
Authors: Al-Howiriny T
Alqasoumi S
Al-Yahya M
Rafatullah S
Issue Date: 2009
Abstract: 'Marjoram,' Origanum majorana L., a culinary aromatic medicinal herb is known to possess various therapeutic properties. We evaluated the antiulcerogenic activity of the ethanol extract in hypothermic restraint stress-, indomethacin-, necrotizing agents- (80% ethanol, 25% NaCl and 0.2 M NaOH) induced ulcers and basal gastric acid secretion using pylorus ligated Shay rat-model. Marjoram at doses of 250 and 500 mg/kg of body weight, significantly decreased the incidence of ulcers, basal gastric secretion and acid output. Furthermore, the extract replenished the ethanol-induced depleted gastric wall mucus and nonprotein sulfhydryls (NP-SH) contents and significantly lowered the increase in the concentration of malondialdehyde (MDA). Ulcer preventing potential was further confirmed by histopathological assessment. An acute toxicity test showed a large margin of safety of the extract in mice. The phytochemical screening of aerial parts of marjoram revealed the presence of volatile oil, flavonoids, tannins, sterols and/or triterpenes.
URI: http://hdl.handle.net/123456789/17731
Appears in Collections:College of Pharmacy

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