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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18384

Title: Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia.
Authors: El-Ansary K, A.
Bacha B, A.
Ayahdi Y, L.
Issue Date: 2011
Publisher: Clin Biochem. 2011 Sep;44(13):1116-20. Epub 2011 Jul 6. Elsevier Inc
Abstract: OBJECTIVE: This study aims to clarify the relationship between blood Pb(2+) concentration as a ubiquitous environmental pollutant and plasma neurotransmitters as biochemical parameters that reflect brain function in Saudi autistic patients. METHODS: RBC's lead content together with plasma concentration of gamma aminobutyric acid (GABA), serotonin (5HT) and dopamine (DA) were measured in 25 Saudi autistic patients and compared to 16 age-matching control samples. RESULTS: The obtained data recorded that Saudi autistic patients have a remarkable higher levels of Pb(2+) and significantly elevated levels of GABA, 5HT and DA compared to healthy subjects. ROC analysis revealed satisfactory values of specificity and sensitivity of the measured parameters. CONCLUSION: This study suggests that postnatal lead toxicity in autistic patients of Saudi Arabia could represent a causative factor in the pathogenesis of autism. Elevated GABA, 5HT and DA were discussed in relation to the chronic lead toxicity recorded in the investigated autistic samples.
URI: http://hdl.handle.net/123456789/18384
Appears in Collections:College of Science

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