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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18417

Title: TP53 genetic alterations in Arab breast cancer patients: Novel mutations, pattern and distribution
Authors: J. Al-Qasem, A.
Toulimat, M.
M. Eldali, A.
Tulbah, A.
Al-yousef, N.
K. Al-Daihan, S.
Al-Tassan, N.
Al-Tweigeri, T.
Aboussekhra, A.
Keywords: TP53, breast cancer , mutations
Issue Date: 2011
Abstract: Breast cancer remains a worldwide public health concern. The incidence and mortality of breast cancer varies significantly in ethnically and geographically distinct popula-tions. In the Kingdom of Saudi Arabia (KSA) breast cancer has shown an increase in incidence and is characterized by early onset and aggressiveness. The tumor suppressor TP53 gene is a crucial genetic factor that plays a significant role in breast carcinogenesis. Furthermore, studies have shown a correla¬tion between certain p53 mutations and response to therapy in breast cancer. In the present study, TP53 mutations were identified by direct sequencing of the gene (exons 4-9) from 119 breast cancer tissues. The prevalence of TP53 mutations in Arab breast cancer patients living in the KSA is among the highest in the world (40%). Notably, 73% of the patients whose tumors harbored p53 mutations were less than 50 years of age. Furthermore, for the first time, we identified 7 novel mutations and 16 mutations in breast cancer tissues. Notably, all the novel point mutations were found in exon 4, wherein 29% of the mutations were localized. Furthermore, an excess of G:C→A:T transitions (49%) at non-CpG sites was noted, suggesting exposure to particular environmental carcinogens such as N-nitroso compounds. The results indicate that the TP53 gene plays a significant role in breast carcinogenesis and the early onset of the disease among Arab female individuals.
URI: http://hdl.handle.net/123456789/18417
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