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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18434

Title: Novel 4-Amino pyrimido[4,5-b]quinoline derivatives as potential Antimicrobial Agents
Authors: E. M. El-Baih, Fatma.
I. Al-Aqeel., Shatha.
A. El-Sayed, Ola.
M. Al-Hazimi, Hassan.
Issue Date: 2002
Publisher: Boll. Chem. Farmac
Citation: Organic chemistry
Abstract: Two series of 4-aminopyrimido[4,5-b]quinoline derivatives substituted in the 2-position 6a-c and/or in 1-position 9a-e have been prepared by facile routes starting from 2-amino-3-cyanoquinoline 2,2-chloro-3-cyanoquinoline 4 and 2-arylamino-3-cyanoquinolines 8a-d. The reactions involved simple fusion with thiourea or urea and, in some cases, with guanidine. The prepared compounds were in vitro tested for antimicrobial activities against some selected Gram-positive, Gram-negative bacteria and fungi. The products containing the thio-function were the most active followed by those containing the imino-function while the carbonyl containing derivatives were without significant antimicrobial effect
URI: http://hdl.handle.net/123456789/18434
Appears in Collections:College of Science

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