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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18437

Title: Sensitive assay for clavulanic acid and sulbactam in pharmaceuticals andblood serum using a flow-injection chemiluminometric method
Authors: A. Aly, Fatma.
A. Alarfaj, Nawal.
A. Alwarthan, Abdulrahman.
Keywords: Sulbactam sodium; Clavulanic acid; Luminol; Chemiluminescence detection; Flow injection; Pharmaceutical preparations;Biological fluids
Issue Date: 2000
Publisher: ©2000 Elsevier Science B.V.
Citation: AnalyticaChimicaActa 414 (2000) 15–23
Abstract: Asensitive, simple and inexpensive chemiluminescence (CL) method using flowinjection is described for the determination of two beta-lactamase inhibitors sulbactam sodium and clavulanic acid (potassium salt) in their pure form, in pharmaceutical preparations and added to blood serum. The method is based on the enhancing effect of these compounds on the CL generated by the oxidation of luminol with hydrogen peroxide in alkaline medium. The CL intensity is a linear function of sulbactam sodium concentration over the range 0.1–150µgml−1 with a detection limit (2×noise) of 0.05µgml−1, and for clavulanic acid over the range 0.01–12µgml−1 with a detection limit of 0.01mgml−1. The method is applied successfully to the determination of the drugs in their dosage forms without interference from co-formulated drugs. The method is specific for the intact drugs in the presence of their degradation products.
URI: http://hdl.handle.net/123456789/18437
ISSN: 0003-2670
Appears in Collections:College of Science

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