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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18440

Title: Spectrofluorimetric determination of prenalterol hydrochloride in pharmaceutical preparations and biological fluids
Authors: A. Aly, Fatma.
Keywords: Fluorimetry; Biological samples; Pharmaceuticals; 2-Cyanoacetamide; Prenalterol hydrochloride .
Issue Date: 1999
Publisher: © 1999 Elsevier Science B.V.
Citation: Journal of Pharmaceutical and Biomedical Analysis
Abstract: A simple and highly sensitive fluorimetric method was developed for the routine determination of prenalterol hydrochloride in bulk, in dosage forms and in biological fluids. The method is based on the fluorescence induced by reaction of the nitroso-derivative of prenalterol hydrochloride with 2-cyanoacetamide in the presence of ammonia. The different experimental parameters were carefully studied and incorporated into the procedure. The fluorescence is measured at 440 nm after excitation at 368 nm. Fluorescence intensity is a linear function of prenalterol hydrochloride concentration over the range of 0.1–2.8 µg ml_1 in the solution finally measured. A proposal for the reaction pathway was suggested.
URI: http://hdl.handle.net/123456789/18440
ISSN: 0731-7085
Appears in Collections:College of Science

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