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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18444

Title: New Approaches for the Synthesis of 1,3,4-Thiadiazole and 1,2,4-Triazole Derivatives with Antimicrobial Activity
Authors: W Wardakhan, Wagnat.
N. E. El-Sayed, Nahed.
Keywords: Antimicrobial; coumarin; thiadiazole; triazole.
Issue Date: 2009
Publisher: Phosphorus, Sulfur, and Silicon, 184:1–15, 2009Taylor & Francis Group, LLC
Citation: Phosphorus, Sulfur, and Silicon, 184:1–15, 2009
Abstract: The thiosemicarbazide derivatives 3a and 3b were cyclized in the presence of concentrated sulfuric acid to give the 5-cyanomethyl-1,3,4-thiadiazole derivatives 4a and 4b, respectively. The latter products were used for many heterocyclic transformations to form coumarin, 1,3,4-thiadiazolo[4,5-a]pyridine, and 5-thiophenylthiophene. In addition, compound 3b underwent cyclization in NaOH (2 N) solution to give the 1,2,4-triazole derivative 16. The reactivity of the latter product towards some chemical reagents was studied. The antimicrobial activities of the newly synthesized products were measured and showed high activities.
URI: http://hdl.handle.net/123456789/18444
ISSN: 1042-6507 print / 1563-5325 online
Appears in Collections:College of Science

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