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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18445

Title: Synthesis and evaluation of antidepressant and sedative activities of some benzo[b] thiophenes.
Authors: W.Warddakhan, Wagnat.
N. E. El-Sayed, Nahed.
Keywords: Benzo[b]thiophenes, pyridazines , pyrazoles, antidepresent, sedative activity
Issue Date: 2010
Publisher: The Egyptian Journal of Chemistry
Citation: The Egyptian Journal of Chemistry
Abstract: The coupling reaction of 2-diazo-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene 2 with the 2-aminoprop-1-ene-1,1,3-tricarbonitrile 3 gave the hydrazone derivative 4. Compound 4 underwent ready cyclization to give the pyridazine derivative 5. The Reaction of 4 with hydrazines gave pyrazole derivatives 6a,b. On the other hand, the reaction of 4 with active methylene reagents gave the pyridazine derivatives 7a,b. The latter products were cyclized into the pyrido[3,2-c]pyrimidine derivatives 8a and 8b, respectively. The reaction of 4 with phenylisothiocyanate gave the 1,2,4-triazine derivative 9. The antidepressant and sedative activities of the newly synthesized products were measured.
URI: http://hdl.handle.net/123456789/18445
ISSN: 0449 2285
Appears in Collections:College of Science

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