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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18516

Title: Novel Marine Compounds: Anticancer or Genotoxic?
Authors: M. Arif, Jamal.
A. Al-Hazzani, Amal.
Kunhi, Muhammed.
Al-Khodairy., Fahad.
Issue Date: 2004
Publisher: J Biomed Biotechnol
Abstract: In the past several decades, marine organisms have generously gifted to the pharmaceutical industries numerous naturally bioactive compounds with antiviral, antibacterial, antimalarial, anti-inflammatory, antioxidant, and anticancer potentials. But till date only few anticancer drugs (cytarabine, vidarabine) have been commercially developed from marine compounds while several others are currently in different clinical trials. Majority of these compounds were tested in the tumor xenograft models, however, lack of anticancer potential data in the chemical- and/or oncogene-induced pre-initiation animal carcinogenesis models might have cost some of the marine anticancer compounds an early exit from the clinical trials. This review critically discusses importance of preclinical evaluation, failure of human clinical trials with certain potential anticancer agents, the screening tests used, and choice of biomarkers.
URI: http://hdl.handle.net/123456789/18516
Appears in Collections:College of Science

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