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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18570

Title: The Gln27Glu Polymorphism in b2-Adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis
Authors: H Daghestan, Maha,
Warsy, Arjumand.
H Daghestani, Mazin.
N Al-odaib, Ali.
Eldali, Abdelmoneim.
A Al-Eisa, Nadia.
Al-zhrani, Sabah.
Keywords: Obesity, Polymorphism
Issue Date: 2010
Publisher: Biomed central
Citation: Lipids in Health and Disease 2010, 9:90
Abstract: Background: b2-adrenoceptor (b2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population. We evaluated Gln27Glu polymorphism in the b2AR gene in obese Saudi populations to investigate the association of b2AR gene with obesity and other related metabolic parameters. Design: We studied possible association of Gln27Glu in b2AR gene with body mass index (BMI), anthropometric measurements and other metabolic parameters. The b2AR gene polymorphism (Gln27Glu) was identified by sequencing PCR products representing locus of interest. Based on BMI, the subjects were divided into three groups, normal weight, overweight and obese. The genotype and allele frequency were calculated separately for each group.Results: The allelic frequency of Glu27 did not differ amongst the three groups, though the Glu27 homozygote (Glu/Glu) were more in obese subjects and had higher concentration of triglyceride, leptin and insulin compared to in the Gln27 heterozygotes and Gln/Gln homozygotes. Conclusions: In this study we were able to provide evidence on the influence of Gln27Glu genetic variant of b2ARgene on lipid phenotypes, insulin and leptin levels in the Saudi populations.
URI: http://hdl.handle.net/123456789/18570
Appears in Collections:College of Science

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