Histopathological and Hematological Effects of Dimethoate 40EC on

Abstract

The study investigated the toxic effects of the pesticide Dimethoate 40EC on some blood constituents i.e. RBCs, and WBCs count, hemoglobin content, hematocrit value and blood plasma protein; and on the tissues of selected organs, i.e. liver, kidney, stomach and intestine of the Swiss albino mice. The doses administered were 16mg/kg and 4mg/kg of Dimethoate 40EC and were proportional to what is used in the field. Treated mice showed significant decline in the hemoglobin and hematocrit (PCV) values compared to controls, but no effect was detected on the total plasma protein. Hepatocytes of treated mice showed histochemically marked depletion in glycogen concenrations compared with the controls.Histopathological changes observed in the liver were hepatocyte pycnosis, vacuolation, blood congestion and high lymphocytic infiltration around the central vein. Meanwhile, kidney showed some changes in the cortex at the glomeruli as swollen cellular lining of the Bowman capsule .Moreover, both the stomach and intestine showed high intensity of lymphocytic infiltration, and some enlarged lymph nodes. .