The effect of weight reduction diet on C-Reactive protein level in obese-Adult subjects

Abstract

o study the effect of weight-reduction diet (WRD) on serum high sensitivity C-reactive protein (hs-CRP) level in obese-adult subjects admitted to Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia. Fifty three subjects with body mass index (BMI) ≥ 30 kg m-2 were included in the study. They were placed on energy-restricted diet for 12 weeks. Diet history and food-frequency questionnaire were filled before starting the WRD. Anthropometric measurements [weight, height, BMI and waist circumference (WC)] were taken and blood samples were collected to analyze hs-CRP, total cholesterol, triglyceride, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol before and at the end of the WRD. There is a significant reduction in BMI and WC after applying the WRD program. In addition, hs-CRP level, triglyceride and total cholesterol were significantly reduced after applying the WRD. A significant positive correlation was noted between serum hs-CRP level and measures of adiposity, such as BMI and WC. hs-CRP level is influenced by WC and by BMI in obese-adult subjects and that the WRD decreases serum level of hs-CRP.