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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18717

Title: Flow-injection chemiluminescent determination of metoclopramidehydrochloride in pharmaceutical formulations and biological fluidsusing the [Ru(dipy)32+]–permanganate system
Authors: A. Alarfaj, Nawal.
Keywords: Metoclopramide; Chemiluminescence flow-injection; Potassium permanganate–Tris(2,2'- dipyridyl) ruthenium(II) reaction; Pharmaceuticalanalysis; Biological fluids
Issue Date: 2004
Publisher: © 2004 Elsevier Science B.V.
Citation: Talanta 62 (2004) 255–263
Abstract: A flow-injection (FI) methodology using (2,2'-dipyridyl) ruthenium(II) [Ru(dipy)32+] chemiluminescence (CL) was developed for therapid and sensitive determination of metoclopramide hydrochloride. The method is based on the CL reaction of metoclopramide withRu(dipy)32+ and KMnO4 in a sulfuric acid medium. Under the optimum conditions, a calibration graph was obtained over the concentrationrange 0.005–3.5 µgml−1 with a limit of detection (S/N = 2) of 1 ngml−1. The correlation coefficient was 0.99993 (n = 8) with a relativestandard deviation of 0.48% for 10 determinations of 1 µgml−1 of drug. The method was successfully applied to the determination ofmetoclopramide in pharmaceutical preparations and biological fluids after IP administration of 25 mg kg−1 dose to rats. The eliminationhalf-life was 2.5 ± 0.4 h.
URI: http://hdl.handle.net/123456789/18717
ISSN: 0039-9140
Appears in Collections:College of Science

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