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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18803

Title: Spectrofluorimetric determination of paroxetine hydrochloride in its formulations
Authors: Alarfaj, Nawal.
A. Razeq, Sawsan.
Sultan, Maha.
Keywords: Paroxetin, fluorimetry, spiked plasma
Issue Date: 2006
Publisher: Pharmaceutical Society of Japan
Citation: Chem. Pharm. Bull., V0l. 54 (4) 564-566,
Abstract: A sensitive spectrofluorimetric procedure for the determination of paroxetine-HCl in pharmaceutical formulations and human plasma has been described. The native fluorescence of the drug has been studied under different conditions. Maximum fluorescence intensity was obtained in methanol at 340 nm using 290 nm for excitation. Different surfactants showed negative effect on the fluorescence intensity of paroxetine-HCl. Regression analysis of Beer's plot showed good correlation (r = 0.9999) between fluorescence intensity and concentration over the range of 0.05- 0 4 µgml-1 with lower limit of detection (LOD) of 0.015 µg ml-1. The drug was successfully determined in its tablets with average % recovery of 98.00 + 0.99% which was in accordance with those given by a compendial method. The method was also applied to the determination of paroxetine-HCl in spiked human plasma with average recovery of 77.70 + 1.06%.
URI: http://hdl.handle.net/123456789/18803
ISSN: 0009-2363
Appears in Collections:College of Pharmacy

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