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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18810

Title: - 2, 3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone as Redox Titrant
Authors: Rizk, Mohammed.
S.Toubar, Safaa.
A.Sultan, Maha.
H.Asaad, Shereen.
Keywords: 2,3-dichloro-5-,6-dicyano-1,4-benzoquinone, N-acetylcystein, captopril, ethamsylate, carbocistein , thioctic acid.
Issue Date: 2003
Publisher: Elsevier
Citation: J. Saudi Chem. Soc.; 7, 175 – 186,
Abstract: An oxidimetric titrant 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in glacial acetic acid is used for the semimicro-determination of some sulphur containing drugs such as: N acetylcysteine, captopril, ethamsylate, carbocisteine, and thioctic acid in pure forms as well as in some pharmaceutical dosage forms. The equivalence point is detected potentiometrically using a platinum/calomel electrode system or visually by certain phenothiazine derivatives. Satisfactory percentage recoveries are obtained; (100.61±0.67) for N-acetylcysteine , (99.6±0.7) for captopril ,(100.1±0.74) for ethamsylate, (99.27±1.35) for carbocisteine and (99.7±1.85) for thioctic acid with a minimum quantitative limit about 1 mg. These results are favourably compared statistically with the reference methods. The proposed procedure is characterized by simplicity, accuracy and precision.
URI: http://hdl.handle.net/123456789/18810
ISSN: 1319-6103
Appears in Collections:College of Pharmacy

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