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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18811

Title: Ultraviolet Spectrophotometric Determination of Some Primary Amines Containing
Keywords: Primary amins, tetracyanoethylene, charge transfer complex, amantadine, tranylcypromine sulfate, tranexamic acid.
Issue Date: 2003
Publisher: springer.
Citation: Microchem. Acta, 143, 281 – 285,
Abstract: A spectrophotometric method is described for the quantitative determination of some drugs containing primary amino-group; amantadine hydrochloride, tranylcypromine sulfate and tranexamic acid in their pure forms as well as in some pharmaceutical dosage forms. The procedure is based on the formation of charge transfer complex between tetracyanoethylene (TCNE) as  acceptor and the studied drugs as n donors in presence of acetonitrile as solvent. The spectra of the complexes show maxima at 330 nm with high apparent molar absorpitivities (from 2.1  103 to 2.2  104 L. mol−1 cm−1). Beer's law is obeyed in the concentration ranges 25 75 g/mL, 2 30 g/mL and 5 25 g/ml and the mean percent recoveries are 99.68±0.92, 100.3±0.75 and 99.8±0.76 for amantadine hydrochloride, tranylcypromine sulfate and tranexamic acid, respectively. The proposed method is simple and can be applied to determine these drugs in their pharmaceutical dosage forms. Results are favorably compared with those reported methods.
URI: http://hdl.handle.net/123456789/18811
ISSN: 0026-3672
Appears in Collections:College of Pharmacy

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