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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18821

Title: Spectrofluorometric method for determination of panthenol in cosmotic and
Authors: A., Mostafa.
Shehata, M.
A. Sultan, Maha.
M. Tawakkol, Shereen.
E. Abdel Fattah., Laila.
Keywords: Panthenol, spectrophlorometry, cosmetics, NBD-Cl.
Issue Date: 2003
Publisher: Elsevier
Citation: Saudi Pharmaceutical Journal, 12, 29 –33.
Abstract: A simple and reliable spectrofluorimetric method has been developed for the determination of panthenol in some cosmetic and pharmaceutical preparations. Panthenol, after alkaline hydrolysis is treated with nitrobenzoxadiazole chloride (NBD-Cl). The fluorescent product was found to have excitation max at 480 nm and emission max at 530 nm. The method showed high sensitivity with linearity range from 0.3 to 3 gml-1. The lower limit of detection (LOD) reached 1.95x10-7M. The different experimental parameters affecting the fluorescence intensity were studied carefully and optimized .The proposed method was applied successfuly to the determination of panthenol in some cosmetics and pharmaceutical preparations. The percentage recoveries ± S.D. (n= 9) were 100.12 ± 0.78, 100.79 ± 0.77 and 100.07 ± 0.31 for ampoules, cream and sunscreen gel respectively. A proposal of the reaction pathway was presented.
URI: http://hdl.handle.net/123456789/18821
ISSN: 1319-0164
Appears in Collections:College of Pharmacy

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