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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/18826

Title: Synthesis,antiplatelet aggregation activity, and molecular modeling study of novel substituted-piperazine analogues.
Authors: M. Youssef, Khairia.
A. Al-Omar, Mohamed.
I. El-Subbagh, Hussein.
A. Abou-Zeid, Laila.
M. Abdel-Gader, Abdel-Galil.
G. Haress, Nadia.
S. Al-Tuwaijri., Ali.
Keywords: Synthesis – Piperazine analogues – Antiplatelet aggregation – Molecular modeling studies.
Issue Date: 2011
Publisher: Springer Science+Business Media
Citation: Med Chem Res (2011) 20:898–911
Abstract: New carbamoylpyridine and carbamoylpiperidine analogues containing nipecotic acid scaffold were designed, synthesized, and evaluated for their platelet aggregation inhibitory activity. Molecular modeling investigation was performed and the impact of lipophilicity on activity was also discussed. Structure activity relationship among this series was obtained. N1-[1-(4-bromobenzyl)-3-piperidinocarbonyl]-N4-(2-chlorophenyl)-piperazine hydrobromide (20), and 1,4-bis-[3-[N4-(2-chlorophenyl)-N1 (piperazinocarbonyl)]-piperidin-1-yl-methyl]-benzene dibromide (30) are the most active antiplatelet aggregating compounds in this study, both aconcentration of 0.06 lM.
URI: http://hdl.handle.net/123456789/18826
ISSN: 1554-8120
Appears in Collections:College of Pharmacy

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