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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/18826
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| Title: | Synthesis,antiplatelet aggregation activity, and molecular modeling study of novel substituted-piperazine analogues. |
| Authors: | M. Youssef, Khairia.
A. Al-Omar, Mohamed.
I. El-Subbagh, Hussein.
A. Abou-Zeid, Laila.
M. Abdel-Gader, Abdel-Galil.
G. Haress, Nadia.
S. Al-Tuwaijri., Ali. |
| Keywords: | Synthesis – Piperazine analogues – Antiplatelet aggregation – Molecular modeling studies. |
| Issue Date: | 2011 |
| Publisher: | Springer Science+Business Media |
| Citation: | Med Chem Res (2011) 20:898–911 |
| Abstract: | New carbamoylpyridine and carbamoylpiperidine analogues containing nipecotic acid scaffold were designed, synthesized, and evaluated for their platelet aggregation inhibitory activity. Molecular modeling investigation was performed and the impact of lipophilicity on activity was also discussed. Structure activity relationship among this series was obtained. N1-[1-(4-bromobenzyl)-3-piperidinocarbonyl]-N4-(2-chlorophenyl)-piperazine hydrobromide (20), and 1,4-bis-[3-[N4-(2-chlorophenyl)-N1 (piperazinocarbonyl)]-piperidin-1-yl-methyl]-benzene dibromide (30) are the most active antiplatelet aggregating compounds in this study, both aconcentration of 0.06 lM. |
| URI: | http://hdl.handle.net/123456789/18826 |
| ISSN: | 1554-8120 |
| Appears in Collections: | College of Pharmacy
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