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|Title: ||Expression of Syndecan-1 in Ameloblastoma, KeratocysticOdontogenic Tumor and Dentigerous Cyst|
|Authors: ||AlOtaibi, Ohoud Nasser|
Khounganian, Prof. Rita
|Keywords: ||Oral Medicine & Diagnostic Sciences|
|Issue Date: ||27-Jun-2010 |
|Abstract: ||Syndecan-1 is a major cell surface proteoglycan, which participates in cell-to-cell adhesion, as well as in the interaction of cells with the extracellular matrix. Analysis of the research literature data on syndecan-1 shows the importance of this macromolecule in different normal and pathologic processes. Several reports have demonstrated that the overall expression of syndecan-1 is reduced in carcinoma cells when compared to their normal counterparts. Other studies on various carcinomas have suggested that reduced expression of syndecan-1 is associated with the prognosis of such neoplasms. Three recent studies investigated the expression of syndecan-1 in ameloblastoma. Expression of syndecan-1 in other odontogenic lesions has not been reported.
The aim of this study was to compare the immunohistochemical localization of syndecan-1 between three distinct odontogenic lesions; ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst. Additionally the relevant clinico-pathological data of these lesions were reported and compared with those of previous reports.
In this study 32 ameloblastomas, 26 keratocystic odontogenic tumors, and 21 dentigerous cysts were included. The cases were reviewed and assessed based on the clinical, histological and radiographic data. The demographic and clinical data of the patients were retrospectively collected. Syndecan-1 immunohistochemical staining was evaluated in the three studied lesions.
The data were subjected to simple descriptive and inferential statistical analysis. The mean age of patients with ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst were 27, 30.3, and 30 years respectively. In general, the studied odontogenic lesions showed a predilection for the mandible and the molar regions of the jaws. Gender analysis showed a male predilection for all the studied cases. The immunohistochemical evaluation revealed a decreased expression of syndecan-1 in ameloblastoma compared to keratocystic odontogenic tumor, and dentigerous cyst. Kruskal-Wallis analysis showed that this decrease was significant (P <0.0001). In ameloblastoma the central cells showed higher expression than the peripheral cells (Mann–Whitney test, P < 0.0001), while granular cell and acanthomatous areas demonstrated decreased syndecan-1 immunoreactivity when compared to other patterns of ameloblastoma. In keratocystic odontogenic tumor the epithelial budding denoted decreased syndecan-1 expression while the satellite cysts did not differ from their main cysts. When all the posterior mandibular lesions were analyzed together, the epithelial syndecan-1 expression was significantly lower in lesions that involved the ramus than lesions with no such involvement (Mann–Whitney test, P = 0.03). Decreased syndecan-1 expression of the epithelial cells close to the areas of inflammation was also observed.
The general distribution and localization of syndecan-1 in ameloblastoma, keratocystic odontogenic tumor, and dentigerous cyst as shown by the present data could help to explain the different biological behavior of these lesions.|
|Appears in Collections:||College of Dentistry|
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