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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/19318

Title: Evaluation of the Phytochemical and Biological Properties of Albizia lebbeck Flowers Growing in Saudi Arabia
Authors: El Halim Abdallah, Mohamed Farag Abd
El Gamal, Ali A
Khalil, Ashraf T.
Keywords: Albizia lebbeck
Issue Date: 25-Jun-2011
Abstract: Albizia lebbeck L. ( ( خبل ايزيبللأا is a member of the legume family (Fabaceae) which is the third largest family of flowering plants with more than 18,000 described species. A. lebbeck L. is among the most important tree species imported many years ago from India and well adapted to the harsh environmental conditions of the central part of Saudi Arabia. It is used for furniture, flooring and a variety of agricultural tools. The cut bark yields a reddish-brown gum used as a substitute for gum Arabic obtained from Acacia senegal. A. lebbeck L. has many synonyms such as Acacia, koko, shack-shack, whistling-bean, Sarenh and woman’s tongue. The current literature revealed that some plants belonging to the genus Albizia have possessed medicinal values. Previous phytochemical investigation of different species belonging to genus Albizia afforded different classes of secondary metabolites such as saponins, terpens, alkaloids and flavonoids. Some bioactive compounds were isolated and identified from genus Albizia e.g. triterpenoid saponins (julibroside J29, julibroside J30, julibroside J31) , novel macrocyclic alkaloids (budmunchiamines A, B and C) and two flavonol glycosides (quercitrin and isoquercitrin) which showed different biological activities such as anti-tumor, antiplatelets aggregation and bactericidal activities. Reviewing the current literature for the importance of the plant Albizia lebbeck growing worldwide revealed many biological interests, but nothing was reported concerning the species cultivated in Saudi Arabia. This study was dedicated to the biological investigations of some phytochemical metabolites in A. lebbeck. Preliminary biological evaluation of different extracts of the titled species has been performed and revealed the presence of secondary metabolites exhibiting antibacterial, estrogenic, anti-inflammatory, analgesic and antipyretic activities. The phytochemical investigation of A. lebbeck cultivated in Saudi Arabia resulted in isolation and identification of one novel β- lactam derivative; albactam, in addition to seven knwon compounds; β- Amyrin, 11α, 12α-oxidotaraxerol, 1-O-β-D-glucopyranosyl- [(2S, 3S, 4R, 8E)-2-[(2-R)-hydroxyhexadecanoylamino]-8-tetra-cosene-1, 3, 4-triol, [(2S, 3S, 4R, 8E)-2-[(2’R)-hydroxyhexadecanoylamino]-8-tetra-cosene-1, 3, 4-triol, 3, 7-dimethyloct-1-en-3, 6, 7-triol, rutin and kaempferol-3-O-rutinoside. 11α, 12α-oxidotaraxerol, 3, 7-dimethyloct-1-en-3, 6, 7-triol, ceramide and its glycoside are reported for the first time from the species lebbeck. The new compound, albactam, was subjected to further biological evaluation and it showed anti-aggregatory activity against adenosine diphosphate and arachidonic acid-induced guinea-pigs' platelets aggregation in vitro at doses 208 μg/ml and 172 μg/ml respectively, whereas yields of other compounds were low. Therefore, this study is represented in five parts: - Part 1: The introductory part that includes a review of taxonomic classification of Albizia lebbeck, folkloric uses and biological activities. Furthermore, the isolation of chemical constituents from A. lebbeck are covered in this part. - Part 2: Materials and methods that includes all materials, equipments and techniques used in this study. In addition, the details of the biological evaluation methods, isolation and characterization of isolates are covered. Moreover, detailed preliminary phytochemical screening tests are also presented. - Part 3: Results and discussion includes characterization and structure elucidations of the isolated compounds are listed. - Part 4: Detailed biological screening results for antimicrobial, antipyretic, analgesic, estrogenic and anti-inflammatory activities are presented in the biological investigation part. - Part 5: Includes a list of references found at the end of this thesis
Description: Masters
URI: http://hdl.handle.net/123456789/19318
Appears in Collections:College of Pharmacy

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