DSpace

King Saud University Repository >
King Saud University >
COLLEGES >
Health Colleges >
College of Medicine >
College of Medicine >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2302

Title: Serum resistin is associated with C-reactive protein and LDL-cholesterol in type 2 diabetes and coronary artery disease in a saudi population
Authors: Al-Daghri, N.
Chetty, R.
McTernan, P.G
Al-Rubean, K.
Al-Attas, O.
Jones, A.F.
Kumar, S.
Keywords: Chronic sub-clinical inflammation
Pathogenesis
Cardiovascular
Obesity
T2DM
CHD
Serum resistin
C-reactive protein
Coronary artery disease--Saudi Arabia
Type2 diabetes--Saudi population
Issue Date: 5-Jul-2005
Publisher: Al-Daghri
Citation: Cardiovascular Diabetology: 4(10); 1-6
Abstract: Aims: Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease. Methods: One hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD). Results: Serum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045). Conclusion: The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients.
Description: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://www.cardiab.com/content/4/1/10
http://hdl.handle.net/123456789/2302
Appears in Collections:College of Medicine

Files in This Item:

File Description SizeFormat
Cardiovascular Diabetology.pdf264.63 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Feedback