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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2321

Title: Nitric oxide synthase inhibitor aminoguanidine potentiates iminodipropionitrile-induced neurotoxicity in rats
Authors: Tariq, Mohammad
Khan, Haseeb Ahmad
Al Deeb, Saleh
Al Moutaery, Khalaf
Keywords: Iminodipropionitrile
Nitric Oxide
Vestibular Toxicity
Issue Date: 1999
Publisher: Elsevier Science Ireland
Citation: Neuroscience Letters: 276; 49-52
Abstract: This investigation was undertaken to study the effect of nitric oxide synthase inhibitor, aminoguanidine on iminodipropionitrile (IDPN)-induced neurobehavioral and vestibular toxicity in rats. The dyskinetic syndrome was produced in male Wistar rats by i.p. injections of IDPN (100 mg/kg) for 6 days. Aminoguanidine was administered orally in the doses of 50, 150 and 300 mg/kg, 60 min before IDPN in three different groups. Control rats received vehicle only, whereas another group was treated with 300 mg/kg of aminoguanidine alone (without IDPN). Our results showed that aminoguanidine signi®cantly and dose dependently exacerbated the incidence and intensity of IDPN-induced dyskinetic head movements. Aminoguanidine potentiated IDPN-induced loss of air righting re¯ex. The histopathological examination of inner ear showed aggravation of IDPN-induced degeneration of sensory hair cells in the crista ampullaris by aminoguanidine. These results suggest the role of nitric oxide in IDPN-induced neurobehavioral and vestibular toxicity.
Description: Neuroscience Research Group, Armed Forces Hospital, P.O. Box 7897 (W-912), Riyadh 11159, Saudi Arabia
URI: www.elsevier.com/locate/neulet
Appears in Collections:College of Science

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